FRONT PAGE T04990 ZOVIRAX® OPHTHALMIC OINTMENT (aciclovir) Patient Information Leaflet Read all of this leaflet carefully before you start using this medicine because it contains important information for you. This includes any possible side effects not listed in this leaflet, see section 4. Driving and Using Machines You may experience blurred vision after using Zovirax Eye Ointment. • If you have any further questions, ask your doctor or pharmacist. • If you get any side effects talk to your doctor or pharmacist. Pregnancy and breast-feeding Ask your doctor or pharmacist for advice before using any medicine. It may harm them, even if their signs of illness are the same as yours. This includes medicines obtained without prescription, including herbal medicines. Other medicines and Zovirax Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. It works by killing or stopping the growth of viruses on the front of your eyeball (cornea). Warnings and precautions Talk to your doctor or pharmacist before using Zovirax if: • you wear contact lenses. If you are not sure, talk to your doctor or pharmacist before using Zovirax. Wait until you can see clearly again before driving or using any tools or machines. It is used to treat eye infections caused by the Herpes simplex virus. If you are not sure, talk to your doctor or pharmacist before using Zovirax. What Zovirax is and what it is used for • Your vision may be blurred for 5 to 10 minutes after applying Zovirax. This belongs to a group of medicines called antivirals. Do not use Zovirax if: • you are allergic (hypersensitive) to aciclovir or valaciclovir or any of the other ingredients (listed in Section 6). 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Treatment should continue for at least 3 days after healing is complete. A post-marketing aciclovir pregnancy registry has documented pregnancy outcomes in women exposed to any formulation of Zovirax. The registry findings have not shown an increase in the number of birth defects described amongst Zovirax exposed subjects compared with the general population, and any birth defects showed no uniqueness or consistent pattern to suggest a common cause. Systemic administration of aciclovir in internationally accepted standard tests did not produce embryotoxic or teratogenic effects in rabbits, rats or mice. In a non-standard test in rats, foetal abnormalities were observed but only following such high subcutaneous doses that maternal toxicity was produced. The clinical relevance of these findings is uncertain. During Hokusai's lifetime Japan was a nation ruled by strict social class, a feudal regime and military dictatorship. The Edo period, as this division of Japanese history came to be known, saw great social and economic change and would eventually lead to the downfall of the ruling elite and the beginning of Japan's Modern Age. Foreign influence was beginning to shape the political future of the nation and as a direct consequence of this Japanese culture would begin to affect the West. The Edo period, named after the city of Edo (now present day Tokyo), lasted for over two hundred and fifty years. The rulers of Japan during this time were the Tokugawa Shoguns. Through an unbroken line of fifteen Shoguns, the Tokugawa clan governed Japan and shaped it's destiny. Listed here are just some of the Tokugawa Shoguns and a brief summary of their time as Japan's ruler. 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