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    Ciprofloxacin is indicated for the treatment of infections caused by susceptible isolates of the designated microorganisms in the conditions and patient populations listed below. Uncomplicated Urinary Tract Infections (Acute Cystitis): Ciprofloxacin is indicated for the treatment of uncomplicated urinary tract infections (UTIs) caused by Escherichia coli, Proteus mirabilis, Enterococcus faecalis, or Staphylococcus saprophyticus. Because fluoroquinolones, including Ciprofloxacin, have been associated with serious adverse reactions and for some patients uncomplicated UTI (acute cystitis) is self-limiting, reserve Ciprofloxacin for treatment of uncomplicated UTIs (acute cystitis) in patients who have no alternative treatment options. Complicated Urinary Tract Infections, And Acute Uncomplicated Pyelonephritis: Ciprofloxacin is indicated for the treatment of complicated urinary tract infections (c UTI) caused by Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, Proteus mirabilis, or Pseudomonas aeruginosa and acute uncomplicated pyelonephritis(AUP) caused by Escherichia coli. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ciprofloxacin and other antibacterialdrugs, Ciprofloxacin should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Only required if discharge or other local symptoms present. Gram stained urethral discharge may show gram negative intracellular diplococci but is not a sensitive test at non-urethral sites. If MSM, also collect anal and pharyngeal swab even if asymptomatic at these sites. In asymptomatic patients, a self-collected or practitioner -collected rectal swab for NAAT is sufficient. However, if the patient has ano-rectal symptoms, best practice is for the clinician to examine with a proctoscope and collect swab for NAAT and culture. for microscopy should be collected when the patient has not urinated for at least 1 hour and only if the patient has frank urethral discharge. Squeeze the urethra to express the discharge and collect on urethral swab.

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    CIPROFLOXACIN. 500 mg for 1 dose. Most other infections. By mouth. For Adult. Initially 500 mg twice daily; increased to 750 mg twice daily, in severe or. If the isolate is known to be ciprofloxacin sensitive, a 500 mg stat dose of. Drug treatment Metronidazole 400 mg bd for 7 days or Metronidazole 2 g stat. Ciprofloxacin official prescribing information for healthcare professionals. Includes. Urinary Tract Infections, 250 to 500 mg, every 12 hours, 7 to 14 days.

    For initiation and maintenance prescribing by specialists only. Elbasvir–grazoprevir for treating chronic hepatitis C NICE TA413 Sofosbuvir–velpatasvir for treating chronic hepatitis C NICE TA430 B - Clostridium difficile reduction strategy In an effort to reduce the incidence of Clostridium difficile-assocatied diarrhoea (CDAD) please note that some antibacterials are more likely to generate the problem than others. The antimicrobials in this guidance have been ranked according to risk. Please consider this when prescribing, and use a lower risk antimicrobial where appropriate. C - Upper Respiratory Tract infections Upper Respiratory Tract Infections - management in primary care D - Lower Respiratory Tract infections Lower Respiratory Tract Infections - management in primary care E- Meningitis NICE fever guidelines NICE CG47 Meningitis - management in primary care Prevention of secondary case of meningitis: Only prescribe following advice from on-call Public Health contact via. New Cross Switch board Tel 01902 307999 F- Urinary Tract Infections Urinary Tract Infections - management in primary care Give TARGET UTI leaflet. G- Gastro-intestinal Tract Infections Gastro-intestinal tract infections - management in primary care H- Genital Tract Infections Contact UKTIS for information on foetal risks if patient is pregnant. The following antibiotics may require dose adjustment in patients with reduced renal function. Recommendations are based on creatinine clearance (Cr Cl), which is an estimate of renal function (GFR). Note: This calculation is based on the Cockcroft and Gault formula and is suitable for adults only. Creatinine Clearance is an estimation of GFR, but if the patient is morbidly obese, anuric or in acute renal failure, this equation will not give a true reflection of GFR. Only prescribe to such patients to treat lower urinary tract infection with suspected or proven multidrug resistant pathogens when the benefits of nitrofurantoin are considered to outweigh the risks of side effects.

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