She is upset because she believes people with diabetes cannot eat any 'white' foods. Buttery mashed potatoes with hot sausage gravy are one of Minnie's favorite indulgences. In addition, her doctor started her on a medication to help manage her type 2 diabetes. Minnie is afraid she won't be able to eat her favorite foods, and the new pill will make her gain weight. As her nurse, you try to ease some of Minnie's fears. You first tell her that she can still have her favorite foods if she eats small amounts and takes her medication called metformin. Metformin is an anti-diabetic medication that reduces the amount of blood sugar (glucose) the liver releases and helps muscles use glucose more effectively. The pancreas makes a hormone called insulin that allows glucose to travel from the blood into the muscles and organs. While most published articles on oral anti diabetic therapy approve of metformin, few discuss what should be done if metformin is contraindicated or not tolerated. This article defines metformin intolerance, and discusses various pharmacological options available for persons with type 2 diabetes who cannot take metformin and do not accept/require insulin. Keywords: Metformin intolerance, type 2 diabetes, sulfonylureas, alpha glucosidase inhibitors, pioglitazone, SGLT2 inhibitors, DPP4 inhibitors. Introduction Most persons with type 2 diabetes initiate oral therapy with metformin. However, some patients have contra-indications to metformin, or cannot tolerate the drug, In such cases, an alternative is required. This alternative may be an oral anti diabetes drug (OAD), or an injectable therapy (insulin, glucagon-like peptide 1 receptor agonist [GLPIRA]). More often than not, an OAD is chosen for this purpose. Zoloft tablete Viagra demo Lactic acidosis is rare but serious 50% mortality metabolic complication that can result from drug accumulation. Lactic acidosis is also linked to. Metformin definition a drug used to treat diabetes mellitus = a severe type of diabetes in which the body cannot use glucose. Learn more. Initiating oral anti diabetic drug alternatives to metformin. Metformin intolerance is defined as the inability to tolerate clinically meaningful doses of metformin. Metformin (brand name Glucophage, Glucophage XR, Glumetza, Riomet) is a member of a class of drugs called biguanides that helps lower blood glucose levels by improving the way the body handles insulin — namely, by preventing the liver from making excess glucose and by making muscle and fat cells more sensitive to available insulin. Metformin not only lowers blood glucose levels, which in the long term reduces the risk of diabetic complications, but it also lowers blood triglyceride levels and does not cause weight gain the way insulin and some other oral blood-glucose-lowering drugs do. Overweight, high cholesterol, and high triglyceride levels all increase the risk of developing heart disease, the leading cause of death in people with Type 2 diabetes. Another advantage of metformin is that it does not cause hypoglycemia (low blood glucose) when it is the only diabetes medicine taken. Metformin is typically taken two to three times a day, with meals. The extended-release formula (Glucophage XR) is taken once a day, with the evening meal. The most common side effects of metformin are nausea and diarrhea, which usually go away over time. Medication prescribed for diabetics to help the body respond better to its own insulin and decrease glucose production by the liver, ultimately helping to control a patient's blood sugar level. Metformin definition Metformin - definition of metformin by The Free Dictionary, METFORMIN meaning in the Cambridge English Dictionary Order kamagra oral jelly australiaCan i order propecia onlineCipro 500 for utiMail order ciproDoxycycline acne review Metformin is a medication used for type 2 diabetes and two other conditions that benefit from lowering blood sugars. You can learn more about this. What is Metformin? - Definition, Classification & Uses.. JPMA - Journal Of Pakistan Medical Association. Metformin Define Metformin at. Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of. Metformin countable and uncountable, plural metformins. uncountable A popular oral drug for the treatment of diabetes, having the chemical formula C4H11N. Jul 13, 2017. Metformin is a prescription drug used primarily in the treatment of type II diabetes.